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In pregnant mice given 6, 68, 460, or 760 mcg/kg/day exenatide during fetal organogenesis, skeletal variations associated with slowed fetal growth, including changes in number of rib pairs or vertebral ossifications sites, and wavy ribs were observed at 760 mcg/kg/day, a dose that produced maternal toxicity and yielded systemic exposure 390-times the human exposure resulting from the MRHD of BYETTA based on AUC comparison

The alpaca project (immunizations and blood sampling) has been approved by the animal welfare authority LAVES with the reference numbers 33.9-42502-05-13A351, 33.9-42502-05-17A220 and 33.19-42502-04-22-00210

This matters because the formulation determines the frequency

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12605-010) at 37 C for 5 min after vigorous pipetting

Shahannaz, Tadahisa Sugiura, Taizo Yoshida International Journal of Molecular Sciences.2025